Hepatitis D Virus (HDV) is a circular, negative-strand RNA virus, its genome is approximately 1.7kb and has a double-stranded rod-shaped structure, the genome contains only one open reading frame (ORF) encoding hepatitis delta antigen (HDAg). HDV is a replication-defective virus that requires HBV surface protein (HBsAg) to complete the assembly of its own virus particles. Therefore, patients with HDV infection often have concurrent HBV infection.
Genevoyager has developed a series of AAV products rAAV-1.2×HDV carrying 1.2 copies of the full-length HDV genome by taking advantage of the stable expression of AAV8 in host cells and strong hepatophilicity and combining a series of existing and self-developed (Patent No. CN111218446A) liver-specific promoters. This product can be used in combination with the AAV-HBV series to stably establish HBV/HDV co-infection and help the research of HDV replication mechanisms and the R&D of anti-HDV drugs.
Catalog Number |
Product Name |
Pack Size |
Titer |
Injection Dosage |
Injection Method |
PT-7499 |
r AAV-Ath2-1.2×HDV (TypeⅠ) (G) |
1ml/vial |
1.00E+12vg/ml |
5.00E+10vg/mouse |
tail vein injection |
PT-7497 |
r AAV-hAAT-1.2×HDV (TypeⅠ) (G) |
1ml/vial |
1.00E+12vg/ml |
5.00E+10vg/mouse |
tail vein injection |
Note:
1. The model should be combined with AAV-HBV virus to establish a model of HDV infection.
2. We can customize HDV genomes activated by different liver-specific promoters and their point mutants according to different requirements of customers to facilitate scientific research and antiviral drug development.
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