Hepatitis D Virus (HDV) is a circular, negative-strand RNA virus, its genome is approximately 1.7kb and has a double-stranded rod-shaped structure, the genome contains only one open reading frame (ORF) encoding hepatitis delta antigen (HDAg). HDV is a replication-defective virus that requires HBV surface protein (HBsAg) to complete the assembly of its own virus particles. Therefore, patients with HDV infection often have concurrent HBV infection.
Genevoyager has developed a series of AAV products rAAV-1.2×HDV carrying 1.2 copies of the full-length HDV genome by taking advantage of the stable expression of AAV8 in host cells and strong hepatophilicity and combining a series of existing and self-developed (Patent No. CN111218446A) liver-specific promoters. This product can be used in combination with the AAV-HBV series to stably establish HBV/HDV co-infection and help the research of HDV replication mechanisms and the R&D of anti-HDV drugs.
|
Product Number |
Product Name |
Titer |
| PT-7497 | rAAV8-Ath2-1.2×HDV (AG) | 1.00E+12 vg/mL |
| PT-7499 | rAAV8-Ath2-1.2×HDV (G) | |
| PT-5700 | rAAV8-APOE/AAT1-1.2×HDV(AG) | |
| PT-5699 | rAAV8-APOE/AAT1-1.2×HDV (G) | |
| PT-4845 | rAAV8-EAlb/hAAT-1.2×HDV (G) | |
| PT-4844 | rAAV8-EAlb/hAAT-1.2×HDV(AG) |
Note:(1) Commonly used injection dosage and method: ≥5.00E+10 HBV+5.00E+10 HDV vg/mouse; tail vein injection.
(2) The model needs to be used in combination with AAV-HBV virus to establish a model of HDV.
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
