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AAV-1.2×HDV

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Hepatitis D Virus (HDV) is a circular, negative-strand RNA virus, its genome is approximately 1.7kb and has a double-stranded rod-shaped structure, the genome contains only one open reading frame (ORF) encoding hepatitis delta antigen (HDAg). HDV is a replication-defective virus that requires HBV surface protein (HBsAg) to complete the assembly of its own virus particles. Therefore, patients with HDV infection often have concurrent HBV infection.


Services

Genevoyager has developed a series of AAV products rAAV-1.2×HDV carrying 1.2 copies of the full-length HDV genome by taking advantage of the stable expression of AAV8 in host cells and strong hepatophilicity and combining a series of existing and self-developed (Patent No. CN111218446A) liver-specific promoters. This product can be used in combination with the AAV-HBV series to stably establish HBV/HDV co-infection and help the research of HDV replication mechanisms and the R&D of anti-HDV drugs.

Product Information

Catalog Number

Product Name

Pack Size

Titer

Injection Dosage

Injection Method

PT-7499

r AAV-Ath2-1.2×HDV (TypeⅠ) (G)

1ml/vial

1.00E+12vg/ml

5.00E+10vg/mouse

tail vein injection

PT-7497

r AAV-hAAT-1.2×HDV (TypeⅠ) (G)

1ml/vial

1.00E+12vg/ml

5.00E+10vg/mouse

tail vein injection


Note:

1. The model should be combined with AAV-HBV virus to establish a model of HDV infection.

2. We can customize HDV genomes activated by different liver-specific promoters and their point mutants according to different requirements of customers to facilitate scientific research and antiviral drug development.

Application Cases

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US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

ABOUT US TECHNOLOGY PLATFORM

US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com

China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com

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