〓 General toxicity

Single-dose toxicity

Repeated-dose toxicity: 7 days, 14 days, 28 days, 13 weeks, 26 weeks, 39 weeks

Species: mice, rats, beagle dogs, cynomolgus monkeys, rabbits, miniature pigs

Administration routes: oral, injection (intravenous/intraperitoneal/subcutaneous), dermal, ocular, etc.

〓 Safety pharmacology

Central nervous system (mice, rats)

Respiratory system (mice, rats, dogs, monkeys)

Cardiovascular system (dogs, monkeys)

hERG assay (in vitro)

〓 Reproductive and developmental toxicity

Fertility and early embryonic development toxicity test (Phase I) (rats)

Embryo-fetal development toxicity test (Phase II) (rats, rabbits)

Perinatal toxicity test (Phase III) (rats)

Juvenile animal toxicity test (rats)

〓 Genetic toxicity

Ames test (in vitro)

Micronucleus test (in vitro/in vivo)

Chromosomal aberration test (in vitro)

Mouse lymphoma assay (in vitro)

〓 Special toxicity

Local irritation test (skin, blood vessels, eyes)

Sensitization test (active, passive)

Hemolytic test (in vitro)

In vitro phototoxicity test

Ophthalmic toxicity test

〓 Administration routes

● Intracerebral injection

● Gastric administration

● Oral mucosal administration

● Nasal instillation

● Intrathecal administration

● Intrathoracic injection

● Intraperitoneal injection

● Subcutaneous injection

● Intradermal injection

● Intramuscular injection

● Transdermal administration

● Rectal administration

● Vaginal administration

● Intra-articular administration

● Infraorbital venous plexus administration

● Tail vein injection

● Intrathecal injection

● Intravitreal injection

● Subretinal administration