The genome of hepatitis B virus (HBV) is a loose circular double-stranded DNA (RC DNA). The cccDNA is formed in the nucleus of the host cell as a transcription template to form the pre-genomic RNA (pgRNA) necessary for HBV amplification, which is then formed by reverse transcription in turn. Negative-strand DNA and DNA replication form double-stranded DNA to complete the amplification process of the viral genome.
By taking advantage of the stable existence of AAV genome in host cells and the strong hepatophilicity of AAV type 8, we developed a series of rAAV-HBV1.3-mer WT replicon products carrying 1.3 copies to the full-length HBV genome. This series of products mimics the formation of pgRNA, which is closer to the natural life cycle of the virus and can steadily establish a long-term HBV infection and accelerate the anti-hepatitis B drug development process.
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Product Number |
Product Name |
Titer |
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PT-0717
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rAAV8-1.3×HBV (D-ayw)
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1.00E+12 vg/mL
|
|
PT-7350
|
rAAV8-1.3×HBV (C-adr)
|
|
|
PT-9245
|
rAAV8-1.3×HBV（B-adw)
|
|
|
PT-9244
|
rAAV8-1.3×HBV（B-adw)
|
|
|
PT-8804
|
rAAV8-1.3×HBV (gtF)
|
Note: Commonly used injection dosage and method: ≥1.00E+11 vg/mouse; tail vein injection.
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
US: 3675 Market Street, Suite 200, Philadelphia, PA19104 Tel: +1 (215) 205-6963 | +086 027-65023363
E-mail: hui.wang@genevoyager.com
China: No128, Guanggu 7th Rd, East Lake High-tech Development Zone, Wuhan, China Tel: 17720522078
E-mail: marketing@genevoyager.com
